Click Here to return To Results

 

Dementia in 2 Histologically Confirmed Cases of MS:One Isolated Dementia & One Assoc with Psychiatric Symptoms JNNP 57:353-359, Fontaine,B.,et al, 1994 See this aricle in Pubmed Article Abstract During the past 10 years,considerable attention has been devoted to cognitive impairment in multiple sclerosis.Occasionally this impairment may be so severe that multiple sclerosis presents as a dementia associated with only minor neurological signs and symptoms.The cases of two women affected by multiple sclerosis who presented with a pure dementia are reported.In the first patient,a progressive apragmatic behavioral disturbance with reduced short term memory and learning abilities were the main clinical features.Neuropathological examination of the brain disclosed numerous plaques in the periventricular white matter,with severe atrophy of the corpus callosum.Plaques were also seen in the white matter of both hippocampus and in the columns of the fornix.The impairment of short term memory could be linked to these lesions.Behavioral changes were probably related to the bilateral lesions of the long associative bundles that disconnected the frontal lobes from other parts of the cerebral hemispheres.In the second patient,visual hallucinations were associated with cognitive dysfunction.MRI showed large plaques in the white matter of both left frontal and temporal lobes.Smaller plaques were also present in the periventricular white matter of the occipital lobes,the nature of which were confirmed by a stereotactic biopsy.

Related Tags

(click to filter results - removes previous filter) behavioral disorder dementia intellectual deficit memory,impairment of MRI MRI,abnormal multiple sclerosis multiple sclerosis,cognitive presenttion neuropathology psychiatric problems in neurologic disorders psychosis

Click Here to return To Results